The unprecedented popularity of the use of the “roundup-ready” (RR) system for soybean production begs the question: is there any persuasive reason not to adopt this practice? If national trends are any indication, the answer appears to be: no, for now. Surveys conducted in 2000-1 (Chen et al., 2001) reported that farmers listed the three most important reasons for adopting the genetically modified organism (GMO) technology as: better weed control, reduced herbicide use, and reduced labor demand. Any one of these reasons might be compelling by itself, but the combination seems too good to be true. Currently the major criticisms of the RR system are: there is potentially weak market support due general consumer sentiment against GMO crops and further farmer dependence on Agrochemical behemoths is not the way to improve farming. While both of these criticisms are potentially valid, they are beyond the scope of what an agriculturalist can address. What we can address are the likely biological consequences of the RR system. The short story is that farmers like the technology and they feel that they can justify its use; what can researchers do to help use it in the best possible way?