As nitrogen (N) prices have risen, corn growers are beginning to think about reducing N application rates. Growers are weighing decisions to reduce N rates along with the potential for N losses that may occur because of the form of N used, method of application, and weather conditions. In the past, growers may have increased N application rates to offset the potential for N loss and subsequent yield loss. This practice was considered to be cheap insurance largely because the cost of the extra N fertilizer was cheap. With today’s N and corn prices, this type of insurance may not be so cheap. Thus, revisiting the practices and economics of applying nitrification and urease inhibitors to protect against N loss is relevant.